Peer-reviewed research by Nexcyon.

Martinez SA, Wilson MG, Linton DD, Newbound GC, Freise KJ, Lin T-L, Clark TP. The safety and effectiveness of a long-acting transdermal fentanyl solution compared to oxymorphone for the control of postoperative pain in dogs: a randomized, multicenter clinical study. J. vet. Pharmacol. Therap., 37(4):394-405, 2014. link to article

Freise KJ, Lin T-L, Fan TM, Recta V, Clark TP. Evidence based medicine: the design and interpretation of non-inferiority clinical trials in veterinary medicine.  J Vet Intern Med 27(6):1305-07, 2013. link to article

KuKanich B and Clark TP.  The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 3–19, 2012. link to article 

Freise KJ, Savides MC, Riggs KL, Owens JG, Newbound GC, Clark TP. Pharmacokinetics and dose selection of a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 21–26, 2012. link to article

Freise KJ, Newbound G C, Tudan C, Clark TP. Pharmacokinetics and the effect of application site on a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 27–33, 2012. link to article

Savides MC, Pohland RC, Wilkie DA, Abbott JA, Newbound GC, Freise KJ, Clark TP. The margin of safety of a single application of transdermal fentanyl solution when administered at multiples of the therapeutic dose to laboratory dogs. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 35–43, 2012. link to article 

Freise KJ, Newbound GC, Tudan C, Clark TP. Naloxone reversal of an overdose of a novel, long-acting transdermal fentanyl solution in laboratory Beagles. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 45–51, 2012. link to article

Linton DD, Wilson MG, Newbound GC, Freise KJ, Clark TP. The effectiveness of a long-acting transdermal fentanyl solution compared to buprenorphine for the control of postoperative pain in dogs in a randomized, multicentered clinical study. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 53–64, 2012. link to article

Freise KJ, Linton DD, Newbound GC, Tudan C, Clark TP. Population pharmacokinetics of transdermal fentanyl solution following a single dose administered prior to soft tissue and orthopedic surgery in dogs. J. vet. Pharmacol. Therap. 35 (Suppl. 2), 65–72, 2012. link to article